Cowboys at Giants (Wednesday 8:30pm)
Defending champs are 8-0 on Opening Night. Jason Witten is likely out for the Cowboys (spleen).
Patriots at Titans (Sunday 1pm)
Will the Patriots, who’ve won 8 straight openers, carry a chip from losing last season’s Super Bowl in the final seconds? Will RB Chris Johnson rebound? QB Jake Locker gets a quick test right out of the gate for the Titans.
Bills at Jets (Sunday 1pm)
The Jets were awful offensively in the preseason, but the Bills weren’t much better. DE Mario Williams
should make an immediate impact here.
Dolphins at Texans (Sunday 1pm)
If QB Matt Schaub were healthy last season, it very well could’ve been the Texans in the Super Bowl, not the Patriots. Even without Mario Williams, the Texans have enough D to get past Dolphins QB Ryan Tannehill.
Colts at Bears (Sunday 1pm)
Welcome to the Andrew Luck era! The stats will be good but the wins won’t be plentiful.
Falcons at Chiefs (Sunday 1pm)
Two teams that have their sights set on getting to that upper echelon of their respective conferences.
Eagles at Browns (Sunday 1pm)
The biggest question each and every week for the Eagles is can QB Michael Vick stay healthy.
Rams at Lions (Sunday 1pm)
The Lions look loaded, but can they mature to let their talent show it? Welcome back Jeff Fisher.
Jaguars at Vikings (Sunday 1pm)
RB Maurice Jones-Drew reported after his training camp holdout, but should only be a 3rd down back. As for RB Adrian Peterson, how much playing time will he get as he comes back from his torn acl?
49ers at Packers (Sunday 4:25pm)
Game of the day in what could’ve been the NFC Championship Game if not for Eli Manning and the Giants. Packers have something to prove. Will Randy Moss do the same?
Seahawks at Cardinals (Sunday 4:25pm)
QB Russell Wilson gets the nod for the Seahawks. Does it really matter for the Cards (Skelton or Kolb)?
Panthers at Buccaneers (Sunday 4:25pm)
A road test right off the bat for QB Cam Newton and the Panthers against a Bucs team that greatly disappointed and now has Greg Schiano at the helm as head coach.
Steelers at Broncos (Sunday 8:20pm)
QB Peyton Manning’s first NFL start not in a Colts jersey. He’s got weapons, but can he get them the ball?
Bengals at Ravens (Monday 7pm)
If not for a Lee Evans dropped TD pass, we could be talking about the Super Bowl Champs, no?
Chargers at Raiders (Monday 10:15pm)
Let the Phillip Rivers redepemption tour begin.